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Partially linear hazard regression with varying coefficients for multivariate survival data

机译:多变量生存数据具有不同系数的部分线性风险回归

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摘要

The paper studies estimation of partially linear hazard regression models with varying coefficients for multivariate survival data. A profile pseudo-partial-likelihood estimation method is proposed. The estimation of the parameters of the linear part is accomplished via maximization of the profile pseudo-partial-likelihood, whereas the varying-coefficient functions are considered as nuisance parameters that are profiled out of the likelihood. It is shown that the estimators of the parameters are root "n" consistent and the estimators of the non-parametric coefficient functions achieve optimal convergence rates. Asymptotic normality is obtained for the estimators of the finite parameters and varying-coefficient functions. Consistent estimators of the asymptotic variances are derived and empirically tested, which facilitate inference for the model. We prove that the varying-coefficient functions can be estimated as well as if the parametric components were known and the failure times within each subject were independent. Simulations are conducted to demonstrate the performance of the estimators proposed. A real data set is analysed to illustrate the methodology proposed. Copyright 2008 Royal Statistical Society.
机译:针对多元生存数据,本文研究了具有变化系数的部分线性风险回归模型的估计。提出了一种轮廓伪局部似然估计方法。线性部分参数的估计是通过最大化轮廓伪部分似然性来完成的,而变系数函数被视为是出于可能性而轮廓化的有害参数。结果表明,参数的估计量是根“ n”一致的,并且非参数系数函数的估计量达到了最佳收敛速度。对于有限参数和变系数函数的估计量,获得了渐近正态性。推导并经验检验了渐近方差的一致估计量,这有助于模型的推断。我们证明了可以估算出变系数函数,以及参数成分是否已知以及每个主题内的故障时间是否独立。进行仿真以证明所提出的估计器的性能。分析了真实的数据集以说明所提出的方法。版权所有2008皇家统计学会。

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